Breast Cytopathology

Desmoid fibromatosis of the breast

Breast FNAC showing sheets of bland spindle cells with long fusiform nuclei within matrix. (Papanicolaou x200)

Fibromatous desmoid tumor of the breast
Fibromatous desmoid tumor of the breast

Bone metastasis of lobular breast cancer

Bone metastasis of  lobular breast cancer cells showing  intracitoplasmic vacuolization with typical targetoid appearance. (Papanicolaou x400)

Bone metastasis of breast lobular cancer


Bone metastasis of breast lobular cancer


Lobular breast cancer

A case of lobular breast cancer cells showing  intracitoplasmic vacuolization with typical targetoid appearance. (Papanicolaou x40, x100 oil immersion)

 Lobular Breast Cancer

 Lobular Breast Cancer
Lobular Breast Cancer

Mucinous breast cancer

A case of mucinous breast cancer showing mucus in the background, elevated cellularity, single ductal cells, three dimensional clusters and nuclear atypia.  (Papanicolaou x200)

Mucinous breast cancer

Phylloid breast tumor

Phylloid breast tumor showing predominance of mixoid and cellular stroma over epithelial cells. (Diff Quick ROSE x100)

Ductal breast carcinoma

Ductal breast carcinoma cells showing pseudopapillary structures. (Diff Quick ROSE x100; Papanicolaou x200) Ductal breast carcinoma Ductal breast carcinoma

Breast ductal cells

Cohesive sheets of breast ductal cells showing benign proliferative features including bipolar nuclei dispersed and over the sheets (Papanicolaou x10, x10, Diff Quick)    

Nipple discharge

Serous dense nipple discharge. Rare histiocytes. (Papanicolaou x200)

Breast tumor cells

Clusters of breast tumor cells surrounded by extracellular “colloid” material suggestive of mucinous lesion (Papanicolaou x10, x20, R.O.S.E Diff Quick)mucinous breast cancer

Breast papillary carcinoma

FNAC. Fragment of micro-architecture showing papillae with a fibrovascular core compatible with breast papillary carcinoma (Papanicolaou x10).


Fragment of cohesive epithelial and stromal cells with variable nuclear crowding and overlapping. Single bare bipolar are scattered in the background suggestive of fibroadenoma. (Papanicolaou, x100)

Breast undifferentiated neoplasia

Poorly cohesive malignant cells showing nuclear enlargement and pleomorphism, coarse chromatin and occasional mitotic figure suggestive of breast undifferentiated neoplasia (Papanicolaou x100, x200; Rapid Onsite Evaluation )

Aspiration of stromal breast cells

Breast adipose tissue showing adipocytes and stromal cells. (Papanicolaou, x100)

Invasive ductal breast carcinoma

Intermediate grade of invasive ductal breast carcinoma showing poorly cohesive malignant cells, single and in clusters, nuclear enlargement and pleomorphism. (Papanicolaou, x400)

Lymphoproliferative breast disease

Cellular smear composed of dispersed single cells with spherical nuclei and coarsely granular chromatin. Most nuclei contain conspicuous multiple nucleoli. Mitotic figures are present. The case is suggestive of breast lymphoproliferative disease. (Papanicolaou, x200)

Breast mastitis

Breast mastitis showing neutrophils and epithelioid cells, histiocytes and debris in the background. (Papanicolaou, x200)

Breast apocrine cells

Breast apocrine cells obtained from benign cyst fluid showing a typical aggregate of oxyphilic cells with abundant cytoplasm and enlarged but bland nuclei. (Papanicolaou, x400) Apocrine metaplasia

Breast carcinoma cells

Breast carcinoma with apocrine differentiation showing irregular clusters of malignant cells with pleomorphic nuclei and prominent nucleoli. (Papanicolaou, x400)   


Aspirate from breast fibroadenoma showing large sheets of cohesive epithelial cells in a typical glove finger structure. (Papanicolaou, x100)

Nipple discharge.

Intraductal papilloma showing a pseudo papillary group of benign ductal cells. (Papanicolaou, x200)

Breast Cystic lesion

Cyst macrophages and a group of epithelial cells in a pseudo papillary structure. (Papanicolaou, x100)

Ductal Breast Carcinoma cells

Infiltrating ductal breast carcinoma showing a cluster of malignant cells. (Papanicolaou x400, Diff-Quik-ROSE x200)

Lobular hyperplasia

Lobular hyperplasia showing numerous acinar cells in lactating patient. (Papanicolaou, x200, x100)