Effusions Cytopathology

Breast cancer pleural effusion

Cell block. Pleural effusion showing clusters of neoplastic cells from a case of metastatic breast cancer Er and PgR positive by immunohistochemistry.(Hematoxylin Eosin x100, x200)

Breast cancer pleural effusion

Pleuric Mesothelioma

Pleural effusion showing a cluster of neoplastic cells from a case of malignant mesothelioma.(Papanicolaou x100 oil immersion)


Ovarian cancer abdominal effusion

Isolated and pseudopapillary groups of neoplastic cells associated to  psammoma bodies and inflammatory cells. CA125 (on the left) and Napsin A (right) resulted positive by immunocytochemistry. (Papanicolaou x400, x200)Abdominal effusion CEA-Napsin A positive


Malignant pleural effusion

Adenocarcinoma cell clusters / balls with large citoplasmatic vacuolization (Papanicolaou, x200) 

adenocarcinoma pleural effusions

Lung adenocarcinoma pleural effusion

Lung adenocarcinoma cells “mimicking” mesothelial cells. The immunocytochemistry resulted TTF-1 positive. (Papanicolaou x100, x200)

Ovarian cancer abdominal effusion

A case of ovarian cancer cells CA125 positive by immunocytochemistry. (Papanicolaou x400, x200) Abdominal ovary metastasis

Pancreatic cancer abdominal effusion

A case of pancreatic cancer. Morphology and immunocytochemistry support the origin of the cells. (Papanicolaou x 200)pancreatic cells, abdominal effusion CEA, CK-19, CK-17

Mesothelial cells

Reactive pleural effusion. Normal mesothelial cells. (Papanicolaou x200)

Breast carcinoma pleural effusion

Metastatic lobular breast carcinoma Estrogen Receptor positive by immunocytochemistry. (Papanicolaou x200)lobular breast cancer pleural effusion  

Pleural and pericardial effusion adenocarcinoma cells

Lung adenocarcinoma cells observed in a case with concomitant pleural and pericardial malignant effusion (Papanicolaou x200)

Lung adenocarcinoma pleural effusion

Malignant pleural effusion cells from lung adenocarcinoma . Immunoreactivity for CK 7 (left) and TTF-1 (right) confirmed the diagnosis. (Papanicolaou x100, x200)pleuck7-ttf1

Ovarian adenocarcinoma effusion

Peritoneal effusion. Cells of mucinous ovarian adenocarcinoma (Papanicolaou x100, x400)

Squamous cell carcinoma pleural effusion

Metastatic squamous cell carcinoma of the lung (Papanicolaou, x200)

Adenocarcinoma cells pleural effusion

Adenocarcinoma cells (Papanicolaou, x200)  

Normal mesothelial cells

Pleural effusion showing monolayered sheet of normal mesothelial cells demonstrating “spongiotic” separation of individual cells within the sheet. (Papanicolaou, x100)

Reactive pleural effusion

Reactive pleural effusion showing acute and chronic cells, normal mesothelial cells and alveolar macrophages in aggregates and dispersed cells with rounded nuclei and vacuolated cytoplasm. (Papanicolaou, x100) Reactive pleural effusion

Breast adenocarcinoma pleural effusion. 

Spheroid aggregate of metastatic ductal cell adenocarcinoma of the breast in a smear of pleural effusion. (Papanicolaou, x100) breast cancer pleural effusion

Lung adenocarcinoma pleural effusion

Lung adenocarcinoma pleural effusion showing pseudopapillary clusters of cancer cells. TTF-1 immunocytochemistry shows nuclear positivity confirming lung origin of the cells. (Papaniclaou, x200)

Ovarian adenocarcinoma effusion

Smear of peritoneal effusion showing cells of metastatic ovarian papillary serous adenocarcinoma containing a psammoma body (on the left). (Papanicolaou, x200)

 Mesothelioma pleural effusion. 

Smear of pleural effusion showing papillary fragments of malignant mesothelioma. (Papanicolaou, x200, x400)

Small cell carcinoma pleural effusion 

Smear of pleural effusion showing small cell carcinoma with typical tiny chain and molding. (Papanicolaou, x400)microcitoma pleural effusion

Ovarian adenocarcinoma effusion

Smear of peritoneal effusion showing metastatic ovarian adenocarcinoma cells resulted CA-125 positive. (Papanicolaou, x400)ca125 breast cancer