GI, Liver and Pancreas Cytopathology

Gastric Adenocarcinoma

Groups and aggregates of adenocarcinoma cells obtained after gastric washing (Papanicolaou x200,x400

Gastric ADK
Gastric ADK

CPRE. Cholangiocarcinoma

Neoplastic cells from a case of cholangiocarcinoma (Papanicolaou x200,x400).

 

EUS-FNA. Pancreatic adenocarcinoma.

Clusters of pancreatic adenocarcinoma cells showing abnormalities such as nuclear enlargement and coarse chromatin(Papanicolaou x200, Diff-Quik stain)

 Pancreatic adenocarcinoma

 EUS-FNA. Pancreatic Endocrine Tumor.

Relatively monotonous sometimes round to polygonal neoplastic cells arranged singly or in clusters suggestive of endocrine tumor(Papanicolaou x100, x200)endocrine tumor

EUS-FNA. Pancreatic Adenosquamous Carcinoma.

Markedly atypical clusters and isolated glandular and squamous cells associated to debris and inflammatory cells on the background.  (Papanicolaou x100, 200)adenosquamous pancreatic cancer

 EUS-FNA. Pancreatic Endocrine Tumor

A case of pancreatic endocrine tumor showing basophilic cytoplasm, nuclear pleomorphism, multi nucleation and prominent nucleoli. Endocrine diagnosis was supported by immunohistochemistry (Papanicolaou x200)endocrine pancreatic neoplasia

Liver FNAB. Liver metastasis of neuroendocrine tumor.

Liver FNAB. Liver metastasis of neuroendocrine tumor. (Papanicolaou x200)

 Adenocarcinoma of the pancreas

Single and large neoplastic multinucleated cells suggestive of osteoclastic adenocarcinoma of the pancreas (Papanicolaou x200) Pancreatic cancer- osteoclasticPancreatic cancer-osteoclasticPancreatic cancer-osteoclastic

CPRE. Cholangiocarcinoma

Neoplastic cells from a case of cholangiocarcinoma (Papanicolaou x200, x100, x200).cholangiocarcinomacholangiocarcinomacholangicarcinoma

Anaplastic pancreatic carcinoma

Anaplastic pancreatic carcinoma showing pleomorphic,  mononuclear and multinucleate neoplastic cells (Papanicolaou x200).
Anaplastic pancreatic cancer

Normal hepatocytes

Normal hepatocytes showing intra cytoplasmic granular pigments, round and regular nuclei with prominent nucleoli (Papanicolaou x400)
 Normal liver cells

Normal pancreatic glandular cells

Normal pancreatic glandular cells obtained after Endoscopic Retrograde Cholangiopancreatography (CPRE) (Papanicolaou x100, x200)
cpre

Pancreatic adenocarcinoma

Pancreatic adenocarcinoma presenting cohesive epithelial cells with nuclear crowding, overlapping, nuclear atypia and mitosis. (Papanicolaou x200, Rapid On Site Evaluation x100)

Liver metastasis

Liver metastasis of neuroendocrine tumor confirmed by immunohistochemistry on the biopsy. (Papanicolaou x100, x400)

Neuroendocrine pancreatic carcinoma

Neuroendocrine pancreatic carcinoma showing dispersed population of cells with moderate anisokaryosis and fragile cytoplasm. Neuroendocrine CD 56 marker immunostaining resulted positive. (Papanicolaou, x200)

Hepatocellular carcinoma

Naked and large round nuclei with macro nucleoli suggestive of hepatocellular carcinoma. (Papanicolaou, x400)

 Mucinous pancreatic adenocarcinoma

Malignant epithelium showing pleomorphism and irregular nuclei suggestive of mucinous pancreatic adenocarcinoma. (Papanicolaou, x400)

 Pancreatic neoplasia

Atypical epithelium showing pleomorphism and irregular nuclei suggestive of pancreatic neoplasia. (Papanicolaou, x400)

 Mucinous pancreatic adenocarcinoma

Malignant epithelium showing pleomorphism, irregular nuclei and cytoplasmatic vacuolization suggestive of mucinous pancreatic adenocarcinoma. (Papanicolaou, x400)

 Pancreatic adenocarcinoma

Malignant epithelium representative of pancreatic adenocarcinoma. Necrotic debris in the background. (Papanicolaou, x200)

Pancreatic adenocarcinoma

Moderately differentiated pancreatic adenocarcinoma showing a cohesive cluster with acinar arrangements. (Papanicolaou, x400)

Pancreatic tubulo-papillary neoplasm

Pancreatic tubulo-papillary neoplasm fragment showing small tumor cells and discontinuous outer border sometimes scattered in the background. (Papanicolaou, x200, x100)

Pancreatic neuroendocrine tumor

Pancreatic neuroendocrine tumor. Dispersed population and little aggregates of small cells with round nuclei, moderate anisokaryosis and fragile cytoplasm . CD 56 neuroendocrine immunocytochemistry marker showing cytoplasmatic positivity confirming the cytomorphology diagnoses.(Papanicolaou, x2oo)

Pancreatic adenocarcinoma

A group of malignant cells showing coarse chromatin and variations in nuclear size and shape suggestive of moderately differentiated adenocarcinoma. (Papanicolaou, x400)

A monolayer sheet of ductal epithelium during pancreatic EUS-FNA procedure

A monolayer sheet of ductal epithelium with honeycomb cell borders and slight variation in nuclear sizes and chromatin can be aspirated during pancreatic EUS-FNA. Morphology is suggestive of duodenal cells contamination. (Papanicolaou, x200)

Pancreatic adenocarcinoma

Malignant epithelium showing pleomorphism and irregular nuclei, macronucleoli suggestive of pancreatic adenocarcinoma. (Papanicolaou/Rapid On Site Evaluation Diff Quick staining, x400)
ADK pancreas